AIT (Aromatase Inhibition Therapy)
You do the work… Long weeks of heavy pumping, your training partner singing the same song in your ear in every workout (“Burn, baby! Burn!”), strong dieting and a sound pro-hormone cycle. You’re happy with the results, finding it worth having gone every night to bed with Arnold’s philosophy of no pain, no gain. Thus, towards the end of a typical 6-8 cycle, you’ve have gained considerable muscle and strength.
POWERFUL NATURAL SELECTIVE ESTROGEN RECEPTOR MODULATOR
- SHBG (sex hormone-binding globulin) is a protein produced primarily in the liver, although the testes, uterus, brain, and placenta also synthesize it. It serves as a transport carrier, shuttling estrogen and testosterone to sex hormone receptors throughout your body. SHBG also safeguards these vital hormones from degrading too rapidly and prevents their clearance from the body.
- It thus acts as the master regulator of your sex hormone levels, maintaining the delicate balance between estrogen and testosterone critical to overall health and to the maintenance of your gains.
- This complicated molecule itself plays another key role in the body: conveying essential signals to the heart, the brain and adipose (fat) tissue that ensure their optimal function. Mother nature even gave you a special SHBG receptor molecule on cell surfaces that functions much like the ubiquitous vitamin D receptor protein, helping cells communicate with one another. In other words, SHBG itself functions much like a hormone.
- Most testosterone circulating in the bloodstream is bound to either SHBG (60%) or albumin (38%): only a small fraction (2%) is unbound or “free” (pal, are you still with me?).
- Testosterone binds more tightly to SHBG than to albumin. Consequently, only albumin-bound testosterone and free testosterone constitute the bioavailable forms of testosterone, which are accessible to target tissues and carry out the actions of the essential hormone. So, in a nutshell, the bioavailability of testosterone is influenced by the level of SHBG.
- Now, we’re talking. The balance between estrogen and testosterone is extremely important for you: what is disastrous for you is excess estrogen. An effective post cycle therapy must provide you with a powerful natural selective estrogen receptor modulator, preventing the catastrophe of estrogen dominance after weeks of blood, sweat, and tears and assuring a balanced environment between estrogen and testosterone.
STRONG CYCLE SUPPORTER
- Adaptogen Science AIT® is an innovative formula designed to support your gains while keeping SHBG in check.
SPEEDS PRE-CYCLE ENVIRONMENT
Heavy workout fellows using prohormone cycles experience both an increase in aromatase activity and an elevation in SHBG production. The net result is an increase in the ratio of estrogen to testosterone and a decrease in total and free testosterone levels: for their own sake, it is crucial that this skewed ratio is balanced.
After a cycle is discontinued, the prohormones used rapidly leave the body and many guys may be delusional enough to think the gains made while they’re on cycle were all down to them.
The ideal formula must provide you with the power of speeding the pre-cycle environment, thus controlling aromatase activity. The ingredients for that goes as follows:
The perennial herb Tinospora cordifoliais distributed throughout the tropical and subtropical Indian subcontinent and China. In India, it is a fairly common inhabitant of deciduous and dry forests, growing over hedges and small trees. It is one of the major constituents of several Ayurvedic preparations used preferably for general debility, dyspepsia, fever and urinary diseases. Apart from many other studies, the hepato-protective and anti-aromatase potentials validated with respect to Tinosporacordifolia by scientific research include: normalization of altered liver functions caused by alcohol consumption; anti-hepatotoxic activity in toxin-induced liver damage; significant increment in the functional capacities of peritoneal macrophages; prevention of anti-tubercular drugs and bile salts induced hepatic damage;activity against jaundice and hepatitis B and C. The chemical constituents reported in Tinosporacordiofolia belongs to different classes such as alkaloids, di-terpenoidlactones, glycosides, steroids, sesquiterpenoids, phenolics, aliphatic compounds, and polysaccharides.
This potent formula allows you to obtain a huge variety of benefits linked to your goals:
- Increase your LBM
- Decrease your subcutaneous water retention
- Promote a lean, dry, vascular look
- Give profound strength increases
- Boost confidence and mood
Kudzu (Pueraria lobata) is a climbing vine that belongs to the pea family. Its flowers and starchy white roots have been used in traditional Chinese medicine for centuries. Kudzu root is rich in isoflavone glucosides, the most abundant of which are puerarin (daidzein 8-C-glucoside), daidzein anddaidzin (daidzein 7-C glucoside). Essentially, puerarin acts as a traffic cop,regulating glucose by directing toward muscles and away from fat cells and blood vessels.
Puerarin binds to the estrogen receptors in the body and because it brings a lower dose of estrogen to the receptors, it can prevent the body from overproducing estradiol. Estradiol and progesterone are anenergetic pair. When estradiol is lowered, progesterone will naturally be raised. Instead of bringing in an outside source of progesterone, this protocol give the body a chance find its own estradiol-progesterone balance.
Kudzu is associated with an attenuation of the rise of adiponectin, which bring serum concentrations to a level similar to lean controls.
Kudzu extract also stabilizes the activity of liver enzymes, stimulates regeneration of liver tissue, and makes the liver more resistant to damage from an anabolic cycle.
SAMe (S-adenosyl methionine)
SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body and used by the body in three important pathways:
Methylation (contributing methyl groups to activate certain molecules)
The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.)
Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals)
It is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, catecholamines, and other neurotransmitters, such as dopamine and serotonin.
It is required for the synthesis of norepinephrine, dopamine, and serotonin, and also plays a role in other intracellular metabolic pathways. Besides, it facilitates glutathione usage and maintains acetylcholine levels, which help enhance or maintain cognitive function and attenuate or prevent aggression.
SAMelevels may become depleted from sickness and age. There is evidence that it helps to synthesize phosphatidylcholine, which keeps cell membranes fluid, and is used in the brain to make the neurotransmitter acetylcholine.
Thisamino acid has multiple mechanisms of action that are used throughout the body, especially in the liver, which help maintain liver health. It facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant glutathione. When liver function is compromised, glutathione is depleted, which leads to free radical damage.
Medical studies have shown that SAMe has beneficial antioxidant effects on the liver and other tissues, particularly in protecting and restoring liver cell function destroyed by drugs, viruses and environmental toxins. It decreases the production of liver collagen (typical feature of anyanabolic cycle), which leads to the formation of fibrous tissue.
MILK THISTLE EXTRACT
Milk thistleis an edible plant, and its leaves can be eaten like artichokes. The seeds can be roasted and brewed like coffee. This herb contains antioxidants, cell membrane-stabilizing agents, bile secretion-enhancing compounds, or nutrients that prevent depletion of endogenous antioxidants such as glutathione.
Silybum marianum, a constituent of milk thistle, has been used for over 2,000 years as a traditional medicine specifically for liver ailments. Milk thistle protects liver tissue; hastens the restoration of liver cells in damaged liver tissue; decreases liver and bile cholesterol; alleviates inflammation; and limits liver damage resulting from a disrupted oxygen supply.
Scientifically, researchers have found that silymarin, as well as an isolated form of flavonolignan called silybin, can prevent or counteract damage to the liver caused by toxins such as alcohol, acetaminophen (Tylenol) and other drugs, as well as environmental (heavy metals) and bacterial toxins, and even poisons such as those found in the lethal Deathcap mushroom. It also counteracts the stressful effects of an anabolic cycle on the liver, such as lipid peroxidation.The main mechanism of liver damage while on cycle is the depletion of glutathione and, silymarin and silybin actually elevated glutathione levels.
Silybinin also has a crucial rule on the typical adipogenesis that may occur after an anabolic cycle. It presence in pre-differentiated adipocytes appears to concentration-dependently reduce differentiation and triglyceride accumulation. Besides, a highly significant suppression of adipogenic markers is normally observed.
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